EFFECT OF ORAL ROUTE RHIZOME TEMULAWAK (Curcuma xanthorriza Roxb.) ON LIVER DAMAGE OF WHITE MALE RATS (Rattus norvegicus) Sprague dawley STRAIN INDUCED BY ASPIRIN

Ria Renta Uli Sirait, Indri Windarti, Dewi Nur Fiana

Abstract


Aspirin is a non steroidal anti-inflammatory (NSAIDS) which is very widely used and reported has some toxicity. Temulawak (Curcuma xanthorriza Roxb.) is a herb that widely used and known as the hepatoprotective agent . The aims of this research is to determine the effect of oral route temulawak rhizome (Curcuma xanthorriza Roxb.) on the liver damage of white male rats Sprague dawley strain induced aspirin. This research is an laboratory experimental post-test only control group. Subjects are 25 Sprague dawley rats divided into 5 groups: K1: given distilled water; K2: given aspirin at a dose of 90 mg; K3: given aspirin 90 mg and oral route temulawak 1.3 g/kg; K4: given aspirin 90 mg and oral route temulawak with 2.6 g/kg; K5: given aspirin 90 mg and oral route temulawak 5.2 g/kg. From ANOVA, the value of p is p=0.000 (p<0.05) it means that there are significant difference in the amount of hepatocyte cell between the other group. The results of Post Hoc test obtained K1-K2 (p=0.001), K1-K3 (p=0.001), K2-K4 (pc=0.001), K2-K5 (p=0.001), K3-K4 (p=0.001), and K3-K5 (p=0.001) which shows significant difference. The conclusion is that there is hepatoprotective effect of temulawak rhizome oral route provision on the liver damage of rats Sprague dawley strain induced by aspirin.

 

Key words: Aspirin, liver damage, temulawak rhizome.

Full Text:

PDF

Refbacks

  • There are currently no refbacks.