Journal of Pharmaceutical and Natural Resources

Systematic Review: The Antihelminthic Effect of Turmeric Rhizome Extract on Ascaris Parasitic Worm

2025-12-01T15:32:22+00:00

Worm infections remain a significant health issue globally, including in Indonesia. The primary treatment for worms is the use of deworming medication, but this can have side effects. Turmeric produces various secondary metabolites that can be developed as drugs against pathogenic infections. Therefore, a literature review is needed to examine the anthelmintic activity of turmeric against Ascaris worms. This review employed a literature review method, searching for primary data sources in the form of national and international journals from the past 10 years. The results indicate that turmeric rhizomes contain various active antihelminthic compounds that can treat Ascaris worm infections through various mechanisms, including inhibition of microtubulin proteins, muscle paralysis that inhibits motility, and disruption of worm digestion, leading to death. The active compounds in turmeric rhizomes have been shown to have a high affinity for beta-tubulin proteins, which play a key role in Ascaris worm motility.

Indonesian Medicinal Plants for Anticancer

2025-12-01T15:19:03+00:00

The potential of Indonesia's natural wealth of plants to be developed as anticancer agents is enormous, thanks to its abundant biodiversity. Indonesia has become a "natural laboratory" with various plants traditionally used for treatment, including cancer, by local communities. This potential is supported by several primary factors: extensive biodiversity, bioactive compound content, and empirical use in traditional medicine. Several studies have identified several Indonesian plants that show potential as anticancer agents: Tapak Dara (Vinca rosea), Taxol (Taxus sp), Lempuyang Wangi (Zingiber zerumbet), Temu Kunci (Boesenbergia pandurata), Melinjo/Tangkil (Gnetum gnemon), Soursop leaves (Annona muricata), Cloves (Syzygium aromaticum), and Typhonium flagelliforme (Typhonium flagelliforme). Despite its great potential, developing anticancer drugs from Indonesian plants faces several challenges: scientific proof, standardization, high research and development costs, and regulatory and patent aspects. To address these challenges, a comprehensive development strategy is needed, including: Enhancing collaboration between research institutions, universities, the pharmaceutical industry, and the government; Conducting ethnobotanical studies to document traditional knowledge of medicinal plants; Developing standardized herbal formulas (phytopharmaceutics) that have supporting scientific data; Strengthening basic research to identify and test specific bioactive compounds; and Encouraging innovation in the extraction and purification of active compounds.

Evaluation Of Medication Errors In The Prescribing Phase Outpatients With Acute Respiratory Tract Infections At The X Health Center In East Lampung In 2025

2025-12-01T15:17:45+00:00

Medication errors are considered as avoidable or preventable events which can lead to inappropriate medication use, potentially detrimental to the patient's condition, and it can occur in patients with ARI. The aim of this study is to determine the incidence of medication errors during the prescribing phase in patients ARI and the relationship between medication errors and age and number of courses of therapy. It was an observational analytical study with a cross-sectional design. Moreover, sampling was conducted by using accidental random sampling from April 2025 at the X Community Public Health Center. In addition, data were analyzed by using the Chi-square test and it was presented in tabular form. The characteristics of ARI patients are 39% male and 59.4% female, with a predominant age group of 34.3%. 83.3% of patients receive ≤ 4 courses of therapy. The incidence of medication errors is 82.3% which occurs in both administrative and pharmaceutical aspects. There is a relationship between the number of courses of therapy and medication errors (p-value <0.05) which shows that the number of therapy received by the patient is a factor in the incidence of medication errors. There is no relationship between age of the patients and medication errors (p-value >0.05). There is a relationship between the number of therapies and the incidence of medication errors. However, there is no relationship between age and the incidence of medication errors.

Potentially Inappropriate Prescribing (PIP) based on Beers Criteria in Geriatric Patients at the Inpatient Unit of a Hospital in Bandar Lampung

2025-12-01T15:26:48+00:00

Geriatric patients often experience polypharmacy due to multimorbidity. This is a factor that increase the risk of Potentially Inappropriate Prescribing (PIP), which can cause serious health problems. Beers Criteria are one of the guidelines used to identify PIP in geriatric patients. This study aims to evaluate PIP in geratric patients using Beers criteria. This study used a cross-sectional approach. The sampling technique was purposive sampling. The study subjects were the medical records of geriatric patients at the inpatient installation of one of the hospitals in Bandar Lampung, totaling 76 subjects. Geriatric patients at the inpatient unit of one of the hospitals in Bandar Lampung were predominantly male with 48 (63.2%) patients, aged group 60 – 69 years with 45 (59.2%) patients, and receiving ≥5 types of medications with 74 (97.4%) patients. The incidence of PIP was found in 26 (34.2%) patients with a total of 33 PIP events consisting of PIP category 1, 2 and 4, are 16 (48.48%), 9 (27.27%) and 8 (24.24%) events respectively.

A Cross-sectional study: The Relationship of Family Support Toward Level Adherence Therapy And Hospitalization In Outpatient Treatment of Schizophrenia

2025-12-30T10:41:30+00:00

Adherence is one of the essential components in the management of schizophrenia. However, adherence levels remain suboptimal, ranging from 20-89%. Multiple factors, including sociodemographic characteristics and family support have been reported to influence medication adherence and hospitalization rates. This study aimed to investigate relationship between family support, medication adherence, and hospitalization among patients with schizophrenia at the Mental Health Hospital Lampung Province. A cross-sectional study design was employed, and data were collected through patient interviews. Medication adherence was assessed using the Medication Adherence Rating Scale (MARS), while family support was measured using validated and reliability-tested family support questionnaire. A total of 106 patients met the inclusion criteria, of whom 65% demonstrated high levels of medication adherence. The factor including sex (p=0,047), employement status ( p=0,004), and family support (p<0.000) were significantly associated with medication adherence. In addition, age (p=0.019), family support (p<0.001), and medication adherence (p<0,000) were significantly associated with hospitalization. These findings indicate that family support has a positive influence on medication adherence and serves as a protective factor againts at worsening prognosis, as reflected by reduced hospitalization. This study emphasizes the crucial role of family support in achiving successful treatment outcomes in patients with schizophrenia.