Muhammad Aprimond Syuhar


Pemphigus vulgaris is an autoimmune disease with manifestations blister the skin or mucosal surfaces. This can occur because of damage caused by intercellular adhesion IgG autoantibodies, sometimes IgA and IgM especially against desmoglein 3, may also at desmoglein 1, causing the release of epithelial cells known as acantholysis. 56 year old man escorted by his wife with complaints blister wounds all over the body since 1 year ago. At the first time there was vesicles on the chest diameter(2x2 cm). Vesicle is very loose and easily broken. Having broken blister wounds arises. The blister wounds hurt so disturb the patient to sleep. On physical examination found a general state is unwell, compos mentis awareness, good nutrition, blood pressure 120/70 mmHg, pulse: 96x / min regular, respiratory 17 times per minute, temperature 36,3ºC. In dermatological status was found abnormalities in the skin with a universal location, time of the inspection found Looks macular erythema, bullae, crusting, erosion in all parts of the body, generalized distribution, irregular shape, size numuler, demarcated, and uneven surfaces. In laboratory tests of blood glucose results obtained when 158, U + 23.1 mg / dl, creatinine 0.94 mg / dl, AST 24.3 U / L, alanine aminotransferase 24 U / L. Diagnosis in patients with Pemphigus Vulgaris is. Therapy given to these patients is IVFD RL xx GTT / min (micro), dexametason 1 amp / 6 hours, cefotaxime 1 g / 12 hours, Gentamycin injection 80mg / 12 hours, Ranitidine inj 1 amp / 12 hours, and topical mupirocin 2x1 cream 2%. This patient experienced disease caused autoimmune disease, so patients need to undergo treatment that has been prescribed by doctors to improve the quality adversely and prevent further complications.

Keywords: Adult, Pemphigus Vulgaris, autoimmune disease

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