INDONESIAN SIDAGURI (SIDA RHOMBIFOLIA L.) AS ANTIGOUT AND INHIBITION KINETICS OF FLAVONOIDS

Abstract

Abstract

Gout results from overproduction or underexcretion of uric acid and is associated with nucleic acid rich diets and the catalysis of xanthine by Xanthine Oxidase (XO) which produces uric acid.Sidaguri (Sida rhombifolia L) in Indonesian, is a traditional medicinal plant with potential as a remedy against gout. The earlier research reported that flavonoids crude extract from this plant could in vitro inhibit the activity of Xanthine Oxidase (XO) (xanthine: oxygen oxidoreductase EC 1.2.3.2) up to 55% and could be antigout.

Keyword: flavonoids sidaguri leaf ( Sida rhombifolia L., urid acid, xanthine Oxidase

Abstrak

Hasil Gout dari kelebihan atau  berhubungan dengan diet kaya asam nukleat dan katalisis xanthine oleh Xanthine oksidase (XO) yang menghasilkan asam urat. Sidaguri( Sida rhombifolia L) di Indonesia, merupakan tanaman obat tradisional dengan potensi sebagai obat terhadap asam urat. Penelitian sebelumnya melaporkan bahwa flavonoid ekstrak kasar dari tanaman ini bisa in vitro menghambat aktivitas Xanthine oksidase (XO) (xanthine: oksidoreduktase oksigen EC 1.2.3.2) hingga 55% dan sebagai antigout.

Kata kunci: daun Sidaguri ( Sida rhombifolia L)., flavonoids, kadar asam urat, xanthine Oxidase